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Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity
Engagement of the T cell receptor (TCR) with its cognate peptide/MHC initiates a cascade of signaling events that results in T cell activation. Limiting the extent and duration of TCR signaling ensures a tightly constrained response, protecting cells from the deleterious impact of chronic activation...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3901516/ https://ncbi.nlm.nih.gov/pubmed/18827983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-008-8034-0 |
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