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Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells
Nedd4 and Itch are E3 ubiquitin ligases that, in vitro, ubiquitinate similar targets and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 (T(H)2) polarization. To test whether the loss of Nedd4 affects T cells in the same way, we generated...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935464/ https://ncbi.nlm.nih.gov/pubmed/18931680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1670 |
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