Ndfip1 Protein Promotes the Function of Itch Ubiquitin Ligase to Prevent T Cell Activation and T Helper 2 Cell-Mediated Inflammation

Nedd4 family interacting protein-1 (Ndfip1) is a protein whose only known function is that it binds Nedd4, a HECT-type E3 ubiquitin ligase. Here we show that mice lacking Ndfip1 developed severe inflammation of the skin and lung and died prematurely. This condition was due to a defect in Ndfip1(−/−)...

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書誌詳細
主要な著者: Oliver, Paula M., Cao, Xiao, Worthen, George Scott, Shi, Peijun, Briones, Natalie, MacLeod, Megan, White, Janice, Kirby, Patricia, Kappler, John, Marrack, Philippa, Yang, Baoli
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955961/
https://ncbi.nlm.nih.gov/pubmed/17137798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2006.10.012
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