Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration

High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) to liver proteins, and depletion of hepatic glutathione. Impaired fatty acid β-oxidation has been...

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Main Authors: Bhattacharyya, Sudeepa, Pence, Lisa, Beger, Richard, Chaudhuri, Shubhra, McCullough, Sandra, Yan, Ke, Simpson, Pippa, Hennings, Leah, Hinson, Jack, James, Laura
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901280/
https://ncbi.nlm.nih.gov/pubmed/24958141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo3030606
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