Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity

Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids to indicators of oxidative drug metabolism (aceta...

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Pubblicato in:PLoS One
Autori principali: James, Laura, Yan, Ke, Pence, Lisa, Simpson, Pippa, Bhattacharyya, Sudeepa, Gill, Pritmohinder, Letzig, Lynda, Kearns, Gregory, Beger, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514842/
https://ncbi.nlm.nih.gov/pubmed/26208104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131010
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