A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

Immunoglobulin G (IgG) formed during pregnancy against human platelet antigens (HPAs) of the fetus mediates fetal or neonatal alloimmune thrombocytopenia (FNAIT). Because antibody titer or isotype does not strictly correlate with disease severity, we investigated by mass spectrometry variations in t...

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Main Authors: Kapur, Rick, Kustiawan, Iwan, Vestrheim, Anne, Koeleman, Carolien A. M., Visser, Remco, Einarsdottir, Helga K., Porcelijn, Leendert, Jackson, Dave, Kumpel, Belinda, Deelder, André M., Blank, Dennis, Skogen, Björn, Killie, Mette Kjaer, Michaelsen, Terje E., de Haas, Masja, Rispens, Theo, van der Schoot, C. Ellen, Wuhrer, Manfred, Vidarsson, Gestur
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2014
Teme:
Plenary Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901064/
https://ncbi.nlm.nih.gov/pubmed/24243971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-09-527978
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