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RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

Parasympathetic activity decreases heart rate (HR) by inhibiting pacemaker cells in the sinoatrial node (SAN). Dysregulation of parasympathetic influence has been linked to sinus node dysfunction and arrhythmia. RGS (regulator of G protein signaling) proteins are negative modulators of the parasympa...

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Bibliografske podrobnosti
Main Authors: Wydeven, Nicole, Posokhova, Ekaterina, Xia, Zhilian, Martemyanov, Kirill A., Wickman, Kevin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900986/
https://ncbi.nlm.nih.gov/pubmed/24318880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520742
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