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RGS6/Gβ5 complex accelerates I(KACh) gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate
RATIONALE: The parasympathetic reduction in heart rate (HR) involves the sequential activation of m2 muscarinic cholinergic receptors (m(2)R), pertussis toxin-sensitive (Gi/o) heterotrimeric G proteins, and the atrial potassium channel I(KACh). Molecular mechanisms regulating this critical signal tr...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014848/ https://ncbi.nlm.nih.gov/pubmed/20884879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.224212 |
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