RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

Parasympathetic activity decreases heart rate (HR) by inhibiting pacemaker cells in the sinoatrial node (SAN). Dysregulation of parasympathetic influence has been linked to sinus node dysfunction and arrhythmia. RGS (regulator of G protein signaling) proteins are negative modulators of the parasympa...

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Bibliografiska uppgifter
Huvudupphovsmän: Wydeven, Nicole, Posokhova, Ekaterina, Xia, Zhilian, Martemyanov, Kirill A., Wickman, Kevin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900986/
https://ncbi.nlm.nih.gov/pubmed/24318880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520742
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