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RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

Parasympathetic activity decreases heart rate (HR) by inhibiting pacemaker cells in the sinoatrial node (SAN). Dysregulation of parasympathetic influence has been linked to sinus node dysfunction and arrhythmia. RGS (regulator of G protein signaling) proteins are negative modulators of the parasympa...

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Main Authors: Wydeven, Nicole, Posokhova, Ekaterina, Xia, Zhilian, Martemyanov, Kirill A., Wickman, Kevin
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900986/
https://ncbi.nlm.nih.gov/pubmed/24318880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520742
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