cAMP Responsive Element Modulator (CREM) α Mediates Chromatin Remodeling of CD8 during the Generation of CD3(+)CD4(−)CD8(−) T Cells

TCR-αβ(+)CD3(+)CD4(−)CD8(−) “double negative” T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T cells have been claimed to derive from CD8(+) cells that down-regulate CD8 co-receptors and acquire a distinct effect...

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Hlavní autoři: Hedrich, Christian M., Crispín, José C., Rauen, Thomas, Ioannidis, Christina, Koga, Tomohiro, Rodriguez Rodriguez, Noe, Apostolidis, Sokratis A., Kyttaris, Vasileios C., Tsokos, George C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900979/
https://ncbi.nlm.nih.gov/pubmed/24297179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523605
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