Modulation of Nuclear Factor E2-related Factor-2 (Nrf2) Activation by the Stress Response Gene Immediate Early Response-3 (IER3) in Colonic Epithelial Cells: A NOVEL MECHANISM OF CELLULAR ADAPTION TO INFLAMMATORY STRESS

Although nuclear factor E2-related factor-2 (Nrf2) protects from carcinogen-induced tumorigenesis, underlying the rationale for using Nrf2 inducers in chemoprevention, this antioxidative transcription factor may also act as a proto-oncogene. Thus, an enhanced Nrf2 activity promotes formation and che...

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Autors principals: Stachel, Imke, Geismann, Claudia, Aden, Konrad, Deisinger, Florian, Rosenstiel, Philip, Schreiber, Stefan, Sebens, Susanne, Arlt, Alexander, Schäfer, Heiner
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900942/
https://ncbi.nlm.nih.gov/pubmed/24311782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490920
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