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The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation

Urate oxidase transforms uric acid to 5-hydroxyisourate without the help of cofactors, but the catalytic mechanism has remained enigmatic, as the protonation state of the substrate could not be reliably deduced. We have determined the neutron structure of urate oxidase, providing unique information...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Oksanen, Esko, Blakeley, Matthew P., El-Hajji, Mohamed, Ryde, Ulf, Budayova-Spano, Monika
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900588/
https://ncbi.nlm.nih.gov/pubmed/24466188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086651
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