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Large crystal growth by thermal control allows combined X-ray and neutron crystallographic studies to elucidate the protonation states in Aspergillus flavus urate oxidase

Urate oxidase (Uox) catalyses the oxidation of urate to allantoin and is used to reduce toxic urate accumulation during chemotherapy. X-ray structures of Uox with various inhibitors have been determined and yet the detailed catalytic mechanism remains unclear. Neutron crystallography can provide com...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Oksanen, E., Blakeley, M. P., Bonneté, F., Dauvergne, M. T., Dauvergne, F., Budayova-Spano, M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Royal Society 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843968/
https://ncbi.nlm.nih.gov/pubmed/19586953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2009.0162.focus
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