Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps

Triosephosphate isomerase (TIM) is a key enzyme in glycolysis that catalyses the interconversion of glyceraldehyde 3-phosphate and dihydroxy­acetone phosphate. This simple reaction involves the shuttling of protons mediated by protolysable side chains. The catalytic power of TIM is thought to stem f...

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Publicat a:IUCrJ
Autors principals: Kelpšas, Vinardas, Caldararu, Octav, Blakeley, Matthew P., Coquelle, Nicolas, Wierenga, Rikkert K., Ryde, Ulf, von Wachenfeldt, Claes, Oksanen, Esko
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2021
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256706/
https://ncbi.nlm.nih.gov/pubmed/34258011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252521004619
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