Perdeuteration, large crystal growth and neutron data collection of Leishmania mexicana triose-phosphate isomerase E65Q variant

Triose-phosphate isomerase (TIM) catalyses the interconversion of dihydroxy­acetone phosphate and glyceraldehyde 3-phosphate. Two catalytic mechanisms have been proposed based on two reaction-intermediate analogues, 2-phosphoglycolate (2PG) and phosphoglycolohydroxamate (PGH), that have been used as...

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Publicat a:Acta Crystallogr F Struct Biol Commun
Autors principals: Kelpšas, Vinardas, Lafumat, Bénédicte, Blakeley, Matthew P., Coquelle, Nicolas, Oksanen, Esko, von Wachenfeldt, Claes
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2019
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450519/
https://ncbi.nlm.nih.gov/pubmed/30950827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19001882
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