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In Vivo Evolution of a Catalytic RNA Couples Trans-Splicing to Translation

How does a non-coding RNA evolve in cells? To address this question experimentally we evolved a trans-splicing variant of the group I intron ribozyme from Tetrahymena over 21 cycles of evolution in E.coli cells. Sequence variation was introduced during the evolution by mutagenic and recombinative PC...

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Detalhes bibliográficos
Main Authors: Olson, Karen E., Dolan, Gregory F., Müller, Ulrich F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900562/
https://ncbi.nlm.nih.gov/pubmed/24466112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086473
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