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An in vivo selection method to optimize trans-splicing ribozymes
Group I intron ribozymes can repair mutated mRNAs by replacing the 3′-terminal portion of the mRNA with their own 3′-exon. This trans-splicing reaction has the potential to treat genetic disorders and to selectively kill cancer cells or virus-infected cells. However, these ribozymes have not yet bee...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285944/ https://ncbi.nlm.nih.gov/pubmed/22274958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.028472.111 |
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