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Computational prediction of efficient splice sites for trans-splicing ribozymes
Group I introns have been engineered into trans-splicing ribozymes capable of replacing the 3′-terminal portion of an external mRNA with their own 3′-exon. Although this design makes trans-splicing ribozymes potentially useful for therapeutic application, their trans-splicing efficiency is usually t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285945/ https://ncbi.nlm.nih.gov/pubmed/22274956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.029884.111 |
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