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Computational prediction of efficient splice sites for trans-splicing ribozymes

Group I introns have been engineered into trans-splicing ribozymes capable of replacing the 3′-terminal portion of an external mRNA with their own 3′-exon. Although this design makes trans-splicing ribozymes potentially useful for therapeutic application, their trans-splicing efficiency is usually t...

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Bibliografische gegevens
Hoofdauteurs: Meluzzi, Dario, Olson, Karen E., Dolan, Gregory F., Arya, Gaurav, Müller, Ulrich F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285945/
https://ncbi.nlm.nih.gov/pubmed/22274956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.029884.111
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