Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

Maternal obesity and gestational diabetes mellitus (GDM) are associated with obesity and diabetes risk in offspring. We tested whether maternal insulin resistance, which frequently coexists with GDM and obesity, could independently contribute to dysregulation of offspring metabolism. Female mice hap...

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Autors principals: Isganaitis, Elvira, Woo, Melissa, Ma, Huijuan, Chen, Michael, Kong, Wen, Lytras, Aristides, Sales, Vicencia, DeCoste-Lopez, Jennifer, Lee, Kyung-Ju, Leatherwood, Cianna, Lee, Deborah, Fitzpatrick, Connor, Gall, Walter, Watkins, Steven, Patti, Mary-Elizabeth
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Pathophysiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900545/
https://ncbi.nlm.nih.gov/pubmed/24186867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0558
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