Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

Maternal obesity and gestational diabetes mellitus (GDM) are associated with obesity and diabetes risk in offspring. We tested whether maternal insulin resistance, which frequently coexists with GDM and obesity, could independently contribute to dysregulation of offspring metabolism. Female mice hap...

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Detalhes bibliográficos
Main Authors: Isganaitis, Elvira, Woo, Melissa, Ma, Huijuan, Chen, Michael, Kong, Wen, Lytras, Aristides, Sales, Vicencia, DeCoste-Lopez, Jennifer, Lee, Kyung-Ju, Leatherwood, Cianna, Lee, Deborah, Fitzpatrick, Connor, Gall, Walter, Watkins, Steven, Patti, Mary-Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900545/
https://ncbi.nlm.nih.gov/pubmed/24186867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0558
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