Deletion of Individual Ku Subunits in Mice Causes an NHEJ-Independent Phenotype Potentially by Altering Apurinic/Apyrimidinic Site Repair

Ku70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PK(CS)) to repair DNA double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. As expected mutating these genes in mice caused a similar DSB repair-def...

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Autori principali: Choi, Yong Jun, Li, Han, Son, Mi Young, Wang, Xiao-hong, Fornsaglio, Jamie L., Sobol, Robert W., Lee, Moonsook, Vijg, Jan, Imholz, Sandra, Dollé, Martijn E. T., van Steeg, Harry, Reiling, Erwin, Hasty, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900520/
https://ncbi.nlm.nih.gov/pubmed/24466051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086358
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