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Molecular Dynamics Simulation of the Allosteric Regulation of eIF4A Protein from the Open to Closed State, Induced by ATP and RNA Substrates

BACKGROUND: Eukaryotic initiation factor 4A (eIF4A) plays a key role in the process of protein translation initiation by facilitating the melting of the 5′ proximal secondary structure of eukaryotic mRNA for ribosomal subunit attachment. It was experimentally postulated that the closed conformation...

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Bibliografske podrobnosti
Main Authors: Meng, Hongqing, Li, Chaoqun, Wang, Yan, Chen, Guangju
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900488/
https://ncbi.nlm.nih.gov/pubmed/24465900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086104
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