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Molecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibition.

BACKGROUND: Glucose transporter 4 (GLUT4) is an insulin facilitated glucose transporter that plays an important role in maintaining blood glucose homeostasis. GLUT4 is sequestered into intracellular vesicles in unstimulated cells and translocated to the plasma membrane by various stimuli. Understand...

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Main Authors: Suma Mohan, Aswathy Sheena, Ninu Poulose, Gopalakrishnapillai Anilkumar
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science (PLoS) 2010-01-01
Sraith:PLoS ONE
Rochtain Ar Líne:http://europepmc.org/articles/PMC2997047?pdf=render
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