Genetic Variants Synthesize to Produce Paneth Cell Phenotypes that Define Subtypes of Crohn’s Disease

BACKGROUND & AIMS: Genetic susceptibility loci for Crohn’s disease (CD) are numerous, complex, and likely interact with undefined components of the environment. It has been a challenge to link the effects of particular loci to phenotypes of cells associated with pathogenesis of CD, such as Panet...

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Main Authors: VanDussen, Kelli L., Liu, Ta-Chiang, Li, Dalin, Towfic, Fadi, Modiano, Nir, Winter, Rachel, Haritunians, Talin, Taylor, Kent D., Dhall, Deepti, Targan, Stephan R., Xavier, Ramnik J., McGovern, Dermot P. B., Stappenbeck, Thaddeus S.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899786/
https://ncbi.nlm.nih.gov/pubmed/24076061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.09.048
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