Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces

Matrix-activated integrins can form different adhesion structures. We report that nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly-Asp peptide (RGD)-lipid surfaces, whereas they habitually form focal adhesions on rigid RGD glass surfaces. Similar to classic mac...

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Autors principals: Yu, Cheng-han, Rafiq, Nisha Bte Mohd, Krishnasamy, Anitha, Hartman, Kevin L., Jones, Gareth E., Bershadsky, Alexander D., Sheetz, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898747/
https://ncbi.nlm.nih.gov/pubmed/24290759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.040
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