Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) and rigid RGD ligands o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Yu, Cheng-han, Rafiq, Nisha Bte Mohd, Cao, Fakun, Zhou, Yuhuan, Krishnasamy, Anitha, Biswas, Kabir Hassan, Ravasio, Andrea, Chen, Zhongwen, Wang, Yu-Hsiu, Kawauchi, Keiko, Jones, Gareth E., Sheetz, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846324/
https://ncbi.nlm.nih.gov/pubmed/26507506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9672
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