Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) and rigid RGD ligands o...

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Pubblicato in:Nat Commun
Autori principali: Yu, Cheng-han, Rafiq, Nisha Bte Mohd, Cao, Fakun, Zhou, Yuhuan, Krishnasamy, Anitha, Biswas, Kabir Hassan, Ravasio, Andrea, Chen, Zhongwen, Wang, Yu-Hsiu, Kawauchi, Keiko, Jones, Gareth E., Sheetz, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846324/
https://ncbi.nlm.nih.gov/pubmed/26507506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9672
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