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Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

Focal adhesions are mechanosensitive elements that enable mechanical communication between cells and the extracellular matrix. Here, we demonstrate a major mechanosensitive pathway in which α-actinin triggers adhesion maturation by linking integrins to actin in nascent adhesions. We show that deplet...

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Detalhes bibliográficos
Principais autores: Roca-Cusachs, Pere, del Rio, Armando, Puklin-Faucher, Eileen, Gauthier, Nils C., Biais, Nicolas, Sheetz, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625291/
https://ncbi.nlm.nih.gov/pubmed/23515331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220723110
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