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BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis

BAK activation represents a key step during apoptosis, but how it converts into a mitochondria-permeabilizing pore remains unclear. By further delineating the structural rearrangements involved, we reveal that BAK activation progresses through a series of independent steps: BH3-domain exposure, N-te...

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Detalhes bibliográficos
Main Authors: Weber, Kathrin, Harper, Nicholas, Schwabe, John, Cohen, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898696/
https://ncbi.nlm.nih.gov/pubmed/24120870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.010
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