Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase

Nonhomologous end-joining (NHEJ) is one of the major DNA double-strand break (DSB) repair pathways. The mechanisms by which breaks are competently brought together and extended during NHEJ is poorly understood. As polymerases extend DNA in a 5′-3′ direction by nucleotide addition to a primer, it is...

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Hlavní autoři: Brissett, Nigel C., Martin, Maria J., Bartlett, Edward J., Bianchi, Julie, Blanco, Luis, Doherty, Aidan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898472/
https://ncbi.nlm.nih.gov/pubmed/24239356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.016
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