The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells

DNA polymerase lambda (polλ) is a recently identified DNA polymerase whose cellular function remains elusive. Here we show, that polλ participates at the molecular level in a chromosomal context, in the repair of DNA double strand breaks (DSB) via non-homologous end joining (NHEJ) in mammalian cells...

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Main Authors: Capp, Jean-Pascal, Boudsocq, François, Bertrand, Pascale, Laroche-Clary, Audrey, Pourquier, Philippe, Lopez, Bernard S., Cazaux, Christophe, Hoffmann, Jean-Sébastien, Canitrot, Yvan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474058/
https://ncbi.nlm.nih.gov/pubmed/16738138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl380
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