Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ

BACKGROUND: DNA polymerase lambda (Polλ) is a DNA repair polymerase, which likely plays a role in base excision repair (BER) and in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSB). PRINCIPAL FINDINGS: Here, we described a novel natural allelic variant of human Polλ (hPolλ) charac...

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Main Authors: Terrados, Gloria, Capp, Jean-Pascal, Canitrot, Yvan, García-Díaz, Miguel, Bebenek, Katarzyna, Kirchhoff, Tomas, Villanueva, Alberto, Boudsocq, François, Bergoglio, Valérie, Cazaux, Christophe, Kunkel, Thomas A., Hoffmann, Jean-Sébastien, Blanco, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751832/
https://ncbi.nlm.nih.gov/pubmed/19806195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007290
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