Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)) by PKA (cAMP-dependent protein kinase) and...

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Autores principales: Houde, Vanessa P., Ritorto, Maria Stella, Gourlay, Robert, Varghese, Joby, Davies, Paul, Shpiro, Natalia, Sakamoto, Kei, Alessi, Dario R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898322/
https://ncbi.nlm.nih.gov/pubmed/24295069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131324
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