Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)) by PKA (cAMP-dependent protein kinase) and...

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Detalhes bibliográficos
Main Authors: Houde, Vanessa P., Ritorto, Maria Stella, Gourlay, Robert, Varghese, Joby, Davies, Paul, Shpiro, Natalia, Sakamoto, Kei, Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898322/
https://ncbi.nlm.nih.gov/pubmed/24295069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131324
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