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The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
Autophagy is an essential cellular pathway for degrading defective organelles and aggregated proteins. Defects in autophagy have been implicated in the neurodegenerative disorder Huntington's disease (HD), in which polyglutamine-expanded huntingtin (polyQ-htt) is predominantly cleared by autoph...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Society for Neuroscience
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898289/ https://ncbi.nlm.nih.gov/pubmed/24453320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1870-13.2014 |
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