Deslivery of GABA(A)Rs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin

The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington’s disease, which is caused by a polyglutamine repeat in the protein huntingtin. However, the machinery that delivers GABA(A)Rs to synapses is unknown. We demonst...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Twelvetrees, Alison E., Yuen, Eunice Y., Arancibia-Carcamo, I. Lorena, MacAskill, Andrew F., Rostaing, Philippe, Lumb, Michael J., Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841506/
https://ncbi.nlm.nih.gov/pubmed/20152113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.12.007
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares