Deslivery of GABA(A)Rs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin

The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington’s disease, which is caused by a polyglutamine repeat in the protein huntingtin. However, the machinery that delivers GABA(A)Rs to synapses is unknown. We demonst...

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Hauptverfasser: Twelvetrees, Alison E., Yuen, Eunice Y., Arancibia-Carcamo, I. Lorena, MacAskill, Andrew F., Rostaing, Philippe, Lumb, Michael J., Humbert, Sandrine, Triller, Antoine, Saudou, Frederic, Yan, Zhen, Kittler, Josef T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841506/
https://ncbi.nlm.nih.gov/pubmed/20152113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.12.007
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