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Drosha Regulates Gene Expression Independently of RNA Cleavage Function
Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically binds promoter-proximal regions of many human genes in a transcription-de...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898267/ https://ncbi.nlm.nih.gov/pubmed/24360955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.032 |
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