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DGCR8 HITS-CLIP reveals novel functions for the Microprocessor
The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. High-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) was used to identify RNA targets of DGCR8 in human cell...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442229/ https://ncbi.nlm.nih.gov/pubmed/22796965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2344 |
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