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Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA
Cotranscriptional cleavage mediated by a hammerhead ribozyme can affect alternative splicing if interposed between an exon and its intronic regulatory elements. This has been demonstrated using two different alternative splicing systems based on α-tropomyosin and fibronectin genes. We suggest that t...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212250/ https://ncbi.nlm.nih.gov/pubmed/18065715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.615508 |
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