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Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA

Cotranscriptional cleavage mediated by a hammerhead ribozyme can affect alternative splicing if interposed between an exon and its intronic regulatory elements. This has been demonstrated using two different alternative splicing systems based on α-tropomyosin and fibronectin genes. We suggest that t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gromak, Natalia, Talotti, Gabriele, Proudfoot, Nicholas J., Pagani, Franco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212250/
https://ncbi.nlm.nih.gov/pubmed/18065715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.615508
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