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Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes

Primary cilia can act as either a negative or positive regulator of the hedgehog (Hh) signaling pathway. Many cartilage tumors are characterized by abnormal activation of the Hh pathway. Here, we report that the presence of primary cilia occurs at a low frequency (12.4%) in neoplastic chondrocytes f...

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Autors principals: Ho, L, Ali, S A, Al-Jazrawe, M, Kandel, R, Wunder, J S, Alman, B A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898120/
https://ncbi.nlm.nih.gov/pubmed/23246966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.588
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