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Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes
Primary cilia can act as either a negative or positive regulator of the hedgehog (Hh) signaling pathway. Many cartilage tumors are characterized by abnormal activation of the Hh pathway. Here, we report that the presence of primary cilia occurs at a low frequency (12.4%) in neoplastic chondrocytes f...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898120/ https://ncbi.nlm.nih.gov/pubmed/23246966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.588 |
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