Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

The TET (ten–eleven translocation) family of α-ketoglutarate (α-KG)-dependent dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethyl-cytosine (5hmC), 5-formylcytosine and 5-carboxylcytosine, leading to eventual DNA demethylation. The TET2 gene is a bona fide tum...

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Bibliografische gegevens
Hoofdauteurs: Yang, H, Liu, Y, Bai, F, Zhang, J-Y, Ma, S-H, Liu, J, Xu, Z-D, Zhu, H-G, Ling, Z-Q, Ye, D, Guan, K-L, Xiong, Y
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897214/
https://ncbi.nlm.nih.gov/pubmed/22391558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.67
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