Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

BACKGROUND: Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. Strain background changes can influence the phenotype of mouse models and can confound crossbreeding studies. We sought to determine if changing the strain backgro...

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Main Authors: Bailey, Rachel M, Howard, John, Knight, Joshua, Sahara, Naruhiko, Dickson, Dennis W, Lewis, Jada
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896770/
https://ncbi.nlm.nih.gov/pubmed/24428919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-8
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