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Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
Dysregulation of glutamate handling ensuing downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is implicated in excitotoxic degeneration of motor neurons in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 (a.k.a. GLT-1) is cleaved by...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896305/ https://ncbi.nlm.nih.gov/pubmed/21769946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21218 |
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