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Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization

EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian CNS. Its dysfunction has been linked to many neurological disorders, including amyotrophic lateral sclerosis (ALS). Decreases in EAAT2 expression and function have...

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Detalhes bibliográficos
Main Authors: Foran, E., Rosenblum, L., Bogush, A., Pasinelli, P., Trotti, D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061158/
https://ncbi.nlm.nih.gov/pubmed/24753081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22677
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