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ROR1 can interact with TCL1 and enhance leukemogenesis in Eµ-TCL1 transgenic mice

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen found on chronic lymphocytic leukemia (CLL) B cells, but not on normal adult tissues. We generated transgenic (Tg) mice with human ROR1 regulated by the murine Ig promoter/enhancer. In contrast to nontransgenic litter...

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Detalhes bibliográficos
Main Authors: Widhopf, George F., Cui, Bing, Ghia, Emanuela M., Chen, Liguang, Messer, Karen, Shen, Zhouxin, Briggs, Steven P., Croce, Carlo M., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896194/
https://ncbi.nlm.nih.gov/pubmed/24379361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308374111
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