Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer

Immunogenic tumors grow progressively even when heavily infiltrated by CD8(+) T cells. We investigated how to rescue CD8(+) T cell function in long-established immunogenic melanomas that contained a high percentage of endogenous PD-1(+) tumor-specific CD8(+) T cells that were dysfunctional. Treatmen...

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Detalhes bibliográficos
Main Authors: Binder, David C., Engels, Boris, Arina, Ainhoa, Yu, Ping, Slauch, James M., Fu, Yang-Xin, Karrison, Theodore, Burnette, Byron, Idel, Christian, Zhao, Ming, Hoffman, Robert M., Munn, David H., Rowley, Donald A., Schreiber, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895468/
https://ncbi.nlm.nih.gov/pubmed/24455752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0058
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