Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix

CTP:phosphocholine cytidylyltransferase (CCT) interconverts between an inactive soluble and active membrane-bound form in response to changes in membrane lipid composition. Activation involves disruption of an inhibitory interaction between the αE helices at the base of the active site and an autoin...

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Detalles Bibliográficos
Main Authors: Lee, Jaeyong, Taneva, Svetla G., Holland, Bryan W., Tieleman, D. Peter, Cornell, Rosemary B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894351/
https://ncbi.nlm.nih.gov/pubmed/24275660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526970
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