Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI)

Tissue factor pathway inhibitor (TFPI) is a Kunitz-type protease inhibitor that inhibits activated factor X (FXa) via a slow-tight binding mechanism and tissue factor-activated FVII (TF-FVIIa) via formation of a quaternary FXa-TFPI-TF-FVIIa complex. Inhibition of TFPI enhances coagulation in hemophi...

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Autors principals: Dockal, Michael, Hartmann, Rudolf, Fries, Markus, Thomassen, M. Christella L. G. D., Heinzmann, Alexandra, Ehrlich, Hartmut, Rosing, Jan, Osterkamp, Frank, Polakowski, Thomas, Reineke, Ulrich, Griessner, Andreas, Brandstetter, Hans, Scheiflinger, Friedrich
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894350/
https://ncbi.nlm.nih.gov/pubmed/24275667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533836
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