IκB Kinase γ/Nuclear Factor-κB-Essential Modulator (IKKγ/NEMO) Facilitates RhoA GTPase Activation, which, in Turn, Activates Rho-associated Kinase (ROCK) to Phosphorylate IKKβ in Response to Transforming Growth Factor (TGF)-β1

Transforming growth factor (TGF)-β1 plays several roles in a variety of cellular functions. TGF-β1 transmits its signal through Smad transcription factor-dependent and -independent pathways. It was reported that TGF-β1 activates NF-κB and RhoA, and RhoA activates NF-κB in several kinds of cells in a...

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Detalhes bibliográficos
Main Authors: Kim, Hee-Jun, Kim, Jae-Gyu, Moon, Mi-Young, Park, Seol-Hye, Park, Jae-Bong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894326/
https://ncbi.nlm.nih.gov/pubmed/24240172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520130
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