The Small GTPase Arf6 Is Essential for the Tram/Trif Pathway in TLR4 Signaling

Recognition of lipopolysaccharides (LPS) by Toll-like receptor 4 (TLR4) at the plasma membrane triggers NF-κB activation through recruitment of the adaptor proteins Mal and MyD88. Endocytosis of the activated TLR4 allows recruitment of the adaptors Tram and Trif, leading to activation of the transcr...

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Detalhes bibliográficos
Main Authors: Van Acker, Tim, Eyckerman, Sven, Vande Walle, Lieselotte, Gerlo, Sarah, Goethals, Marc, Lamkanfi, Mohamed, Bovijn, Celia, Tavernier, Jan, Peelman, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894321/
https://ncbi.nlm.nih.gov/pubmed/24297182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499194
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